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Since then, the FDA said Thursday it has "conducted additional substantive review of the applications in a number of disciplines, including toxicology, engineering, social science, and clinical pharmacology." The reversal is based on a "review of information provided by the applicant" as well as new case law stemming from court decisions involving marketing denial orders, or MDOs, for e-cigarette products, the FDA said

The Original variant is categorized as full strength, meaning stronger perceived nicotine impact and fuller tobacco profile compared to light or medium options

Germain, D., Wakefield, M